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Creators/Authors contains: "Qiang, Wei"

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  1. ; ; ; ; (, USENIX)
    Accepted Manuscript Full Text Available
  2. ; ; ; ; ; ; ; ; ; ; et al (, Biochimica et Biophysica Acta (BBA) - Biomembranes)
    Cell membranes are responsible for a range of biological processes that require interactions between lipids and proteins. While the effects of lipids on proteins are becoming better understood, our knowledge of how protein conformational changes influence membrane dynamics remains rudimentary. Here, we performed experiments and computer simulations to study the dynamic response of a lipid membrane to changes in the conformational state of pH-low insertion peptide (pHLIP), which transitions from a surface-associated (SA) state at neutral or basic pH to a transmembrane (TM) α-helix under acidic conditions. Our results show that TM-pHLIP significantly slows down membrane thickness fluctuations due to an increase in effective membrane viscosity. Our findings suggest a possible membrane regulatory mechanism, where the TM helix affects lipid chain conformations, and subsequently alters membrane fluctuations and viscosity. 
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    Full Text Available 
  3. ; ; ; ; (, Proceedings of the 17th USENIX Symposium on Operating Systems Design and Implementation)
    Accepted Manuscript Full Text Available
  4. ; ; ; ; (, USENIX Symposium on Operating Systems Design and Implementation)
  5. ; ; ; ; (, Proceedings of the 17th USENIX Symposium on Operating Systems Design and Implementation (OSDI 2023))
  6. ; ; ; ; ; ; (, Biophysical Journal)
    Full Text Available 
  7. ; ; ; ; ; ; ; ; ; ; et al (, ACS Infectious Diseases)
    Full Text Available